Conference Agenda
Wednesday 8th May
8:30 onwards Registration and refreshments
9:30 - 9:40 Welcome from the Proteostasis UK Conference Organisers
Chair: Ritwick Sawakar
9:40 - 10:20 Keynote Address:
The Proteostasis Network as a Biological Clock for Health, Aging and Disease
Professor Rick Morimoto; Director of the Rice Institute for Biomedical Research at Northwestern University and Royal Society Wolfson Visiting Fellow at the University of Cambridge
10:20 - 11:00 Flash Talks Session 1 | Chair: Oliver Florey
11:00 - 11:35 Refreshments
Chair: Beatriz Orosa
11:30 - 11:50 Quality control of membrane proteins
Professor Pedro Carvalho, Sir William Dunn School of Pathology, University of Oxford
11:50 - 12:10 The challenges of predicting amyloidogenicity
Professor Sheena Radford, Faculty of Biological Sciences, University of Leeds
12:10 - 12:30 Induced control of protein degradation
Dr Benedict Cross, Chief Technology Officer, PhoreMost
12:30 - 13:05 Flash Talks Session 2 | Chair: Oliver Florey
13:05 - 14:45 Lunch and Poster session
Chair: Simon Cook
14:45 - 15:05 NXP800: a clinical stage GCN2/ISR activator that inhibits HSF1 – mediated transcription for the treatment of ARID1A mutant ovarian cancer
Professor Paul Workman, Signal Transduction & Molecular Pharmacology team, Institute of Cancer Research, London
15:05 - 15:25 Diverse ubiquitin chain topologies orchestrate plant immune signalling
Professor Steven Spoel, Institute of Molecular Plant Sciences, University of Edinburgh
15:25 - 16:10 Flash Talks Session 3 | Chair: Della David
16:10 - 16:50 Refreshments
16:50 - 17:40 Flash Talks Session 4 | Chair: Della David
17:40 - 18:30 Conference Brainstorming: The Future of the Network
18:30 - 21.30 Drinks reception and Conference Dinner at the Babraham Institute
Thursday 9th May
8:30 - 9.15 Refreshments
9.15 - 9.20 Welcome back to Day Two
Chair: Laura Itzhaki
9:20 - 9:40 Deconvoluting cellular proteostasis strategies across proliferative states
Dr Rahul Samant, Group Leader, Babraham Institute
9:40 - 10:00 Exploring lysosomal dysfunction in cellular senescence
Dr Bernadette M Carroll, Senior Research Fellow, University of Bristol
10:00 - 10:20 Dysregulated proteostasis as a virulence mechanism of pathogenic bacteria, the case of the Mycobacterium ulcerans exotoxin mycolactone
Professor Rachel Simmonds, Head of the Department of Microbial Sciences and Professor of Immunopathogenesis,
University of Surrey
10:20 - 10:40 Increased fidelity of protein synthesis extends lifespan
Dr Ivana Bjedov, Principal Research Fellow, Molecular Biology of Cancer Research Group, UCL Cancer Institute
10:40 - 11:10 Refreshments
Chair: Viktor Korolchuk
11:10 - 11:30 Protein phase transitions
Professor Tuomas Knowles, Department of Chemistry, University of Cambridge
11:30 - 11:50 How neuronal signalling connects perception with proteostasis and ageing
Dr Rebecca Taylor, School of Biological Sciences, University of East Anglia
11:50 - 12:50 Panel Discussion: How can our knowledge of proteostasis be translated into therapeutic benefit?
Chair: Kathryn Chapman, Director, Science & Entrepreneurship at Babraham Research Campus
Panel:
- Paul Thompson, Chief Scientific Officer, Mission Therapeutics
- Fiona Menzies, Associate Vice President, Eli Lilly and Company
- James Hunt, R&D Biologics Engineering, AstraZeneca
- Wei-Li (William) Kuan, Head of Biology of the Alborada Drug Discovery Institute, University of Cambridge
- Ralph Minter, Senior Vice President Research, Alchemab Therapeutics
12:50 - 13:10 Conference Brainstorming: Future of the Network Part 2 and Closing Address
13:10 - 14:30 Lunch
Conference End
Conference sponsors
The organisers gratefully acknowledge sponsorship support for the event from:
