Our Network
Members R-Z
Charalampos (Babis) Rallis
School of Biological and Behavioural Sciences, Queen Mary University of London
Co-Coordinating Committee Member
We study proteostasis and its precise links to nutrient-responsive pathways such as the mechanistic target of Rapamycin (mTOR), in cellular space and time. We use the fission yeast Schizosaccharomyces pombe, mammalian 2D and 3D tissue culture systems and C. elegans. We utilise multi-omics approaches, microscopy and network biology. Our aim is to illuminate molecular mechanisms and principles behind senescence and lifespan regulation and apply this knowledge for the amelioration of age-related diseases such as neurodegeneration and cancer.
Keywords: Ageing; Protein translation and ribosomes; Neurodegeneration
David Ron
CIMR, University of Cambridge
Our lab studies mechanisms used by cells to cope with the consequences of deviation from proteostasis in the endoplasmic reticulum (so-called ER stress). Presently we focus on the upstream mechanisms involved in stress signal recognition and on those downstream effector functions that link changes in ER proteostasis to control of mRNA translation (i.e., the Integrated Stress Response, or ISR) and to post-translational regulation of the ER Hsp70 BiP by its reversible AMPylation and de-AMPylation.
Keywords: Protein translation and ribosomes; Stress responses; Protein folding and chaperones
Adrien Rousseau
MRC Protein Phosphorylation and Ubiquitinylation, University of Dundee
Co-Coordinating Committee Member
Our research group focusses on understanding the spatio-temporal regualtion of proteasome homeostasis during stress underlying diseases. We also aim at engineering the proteasome to establish new cell-based assays to identify new factors and drugs modulating proteasome function for potential therapeutic benefits.
Keywords: Protein degradation; Stress responses; Protein translation and ribosomes
Rahul Samant
Signalling Programme, Babraham Institute
Co-Coordinating Committee Member
Our group uses multi-dimensional proteomics, live-cell imaging, and ubiquitin biochemistry to understand how ubiquitin-mediated signalling mediates misfolded protein quality control in healthy and diseased cell contexts. A major current focus is on how the proteostasis network is re-wired in a range of non-proliferative cellular states, with the goal of harnessing vulnerabilities to promote healthy ageing.
Keywords: Ubiquitin; Stress responses; Chaperones; Ageing; Senescence
Ritwick Sawarkar
MRC Toxicology Unit
UK Proteostasis Network Coordinator
Co-Coordinating Committee Member
Our research group focusses on elucidating mechanisms by which mammalian cells sense and respond to proteotoxic stress. We use genetic, biochemical and cell biological approaches and test our hypotheses in mouse models of ageing and neurodegeneration. Our aim is to identify new therapeutic opportunities for proteotoxic diseases.
Keywords: Heat-shock response, Chaperones, RNA therapeutics
Louise Serpell
Sussex Neuroscience, School of Life Sciences University of Sussex
Our research focusses on protein misfolding, self-assembly and toxicity of misfolded proteins. Our work spans structural biology and cellular biology. Currently the focus of the laboratory is on Alzheimer's disease, particularly related to Amyloid-beta and Tau self-assembly and associated neurodegenerative mechanisms.
Keywords: Aggregation; Neurodegeneration; Lysosome
Joe Swift
Manchester Cell-Matrix Centre, University of Manchester
Co-Coordinating Committee Member
My group is interested in how physical inputs are transmitted from matrix to cell, and how cells and tissues are protected from demanding physical environments. We seek to understand how these pathways change during ageing and disease processes, which oftentimes result in tissue stiffening and a diminished cellular capacity for repair and regeneration.
Keywords: Protein folding and chaperones; Ageing; Stress responses
George Tofaris
Kavli Institute for Nanoscience Discovery Nuffield, Department of Clinical Neurosciences, University of Oxford
Co-Coordinating Committee Member
Our aim is to understand fundamental mechanisms that could inform the development of targeted therapies and innovative biomarkers in neurodegeneration with a primary focus on Parkinson's disease. We are currently employing a multifaceted approach encompassing genetic screens, proteomics and transcriptomics in iPSC-based models of increasing cellular complexity and the study of biosamples from clinical cohorts.
Keywords: Neurodegeneration; Aggregation; Protein degradation
Martin Turner
Immunology Programme, Babraham Institute
Our lab Works collaboratively, uses mouse models coupled with transcriptomic and measurement of RNA/protein interactions highlighting the central role in lymphocyte differentiation and function.
Keywords: Ageing; Cancer; Protein translation and ribosomes
David Vaux
Dunn School of Pathology, University of Oxford
We study pathological and physiological catalytic assembly of host molecules into hydrogels and fibrillar amyloid forms, with especial interest in the roles of hydrophobic-hydrophilic interfaces as modulators of these processes.
Keywords: Condensates; Neurodegeneration; Aggregation
Simon Wilkinson
MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, CRUK Scotland Centre
We investigate molecular mechanisms of autophagic recognition and degradation of aggregation-prone proteins from within the ER lumen. This is coupled with investigation of how these processes fail and thus drive formation of cancer, using mouse models and human tissues.
Keywords: Protein degradation; Model organisms(C. elegans, Drosophila, etc); Cancer
Andy Wilson
School of Chemistry, University of Birmingham
We develop and use chemical biology approaches to study and manipulate transient protein-protein interaction of intrinsically disordered regions. We employ enabling methods for drug-discovery, biophysics & structural molecular biology. Target of interest include proteins involved in cancer and aggregation.
Keywords: Aggregation; Cancer; Post-translational modifications (PTMs)
Paul Workman
Centre for Cancer Drug Discovery, The Institute of Cancer Research
Our primary focus is multidisciplinary research to discover innovative precision medicines that exploit the addictions, dependences and vulnerabilities of human cancers. We especially aim to study and exploit abnormal signal transduction and stress response pathways in cancers cells using the approaches of molecular biology, molecular pharmacology and chemical biology. We also collaborate with clinical colleagues to support the clinical evaluation of our new drugs, especially developing biomarkers for use in the Pharmacological Audit Trail.
Keywords: Cancer; Stress responses; Protein folding and chaperones
Wei-Feng Xue
School of Biosciences, University of Kent
We are focused on resolving the fundamental mechanisms that govern the formation and the molecular lifecycle of amyloid protein aggregates, and the relationships between amyloid structures and their roles in biology and in disease.
Keywords: Protein folding and chaperones; Aggregation; Condensates