Biochemistry of Aging Post doc
Fritz Lipmann Institute, Germany
Application Deadline: Sunday 30th November 2025
Research focus of the Lab:
The Kirstein Research Group studies the regulation and activity of the proteostasis network and its role in neurodegenerative diseases. We focus in particular on molecular chaperones and their role in regulating the folding landscape of amyloid proteins such as Huntingtin, Abeta and Tau.
Your tasks:
Postdoc (m/f/x) | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI) | 230
University of Leeds, UK - PhD
Start Date: Thursday 1st October 2026
Application Deadline: Friday 5th December 2025
The project will combine biochemical and biophysical assays to map the pathway(s) of protein aggregation into amyloid. You will also use cryoEM to solve structures formed throughout assembly. By combining these data you will derive new models that describe the molecular events underpinning assembly into different amyloid structures and learn how solution conditions, including cofactors such as the glycosaminoglycans and metabolites that are present in cells but are typically missing in vitro, determine selection of disease-specific amyloid structures. By reproducibly creating the amyloid structures from disease, we will accelerate efforts to diagnose and treat amyloid disease.