A three-part series published in Autophagy presents a comprehensive annotation of the Human Proteostasis Network (PN). Led by the US Proteostasis Consortium, the papers provide a curated framework for understanding the cellular systems that maintain protein homeostasis, creating an invaluable resource for researchers investigating proteostasis in health, ageing, and disease.
Survey of the Human Proteostasis Network: Translation, Protein Folding, and Organelle-Specific Systems
Survey of the Human Proteostasis Network: The Autophagy-Lysosome Pathway
Survey of the Human Proteostasis Network: The Ubiquitin-Proteasome System